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Hypothalamic control of pulmonary renal reflex (718.3)
Author(s) -
Choudhary Rishabh,
Gulati Kavita,
Ravi Krishnan
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.718.3
Subject(s) - cannula , reflex , medicine , lesion , pouch , saline , anatomy , urine , anesthesia , urology , surgery
Pulmonary lymphatic obstruction (PLO) is associated with a reflex increase in urine flow. The central integration of this reflex termed PRR is not known. Thus the aim of the present study is to observe the role of paraventricular nucleus (PVN) on PRR. Experiments were performed on anesthetized, artificially ventilated adult New Zealand white rabbits. After routine cannulations, an isolated venous pouch was created in the right external jugular vein in the neck region. A cannula was positioned in this pouch and the other end of it was connected to a saline reservoir. To cause PLO, the reservoir was raised to a height of 30 cm. The urinary bladder was cannulated for collecting urine. Each rabbit was hydrated by giving saline infusion (rate ‐ 12 ml/10 min). The rabbit was then fixed to a stereotaxic apparatus. A dorsal incision was made and activity from right renal sympathetic nerve (RSN) was recorded. Electrodes were placed on either PVN. Urine was collected every 10 min during the initial control period, during PLO and after releasing PLO each for a period of 20 min. The study was repeated after electrolytic lesion of PVN bilaterally. The significant increases in urine flow and RSN activity observed before lesion were abolished after the lesion. It is concluded that along with an increase in urine flow, there is an increase in RSN activity also during PLO and PVN functions as an integrating centre in PRR. Grant Funding Source : Supported by: CSIR,UGC India