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Changes to erythrocyte markers during lower body negative pressure and graded blood loss in humans (707.3)
Author(s) -
Effertz Cary,
Johnson Blair,
Convertino Victor,
Joyner Michael,
Curry Timothy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.707.3
Subject(s) - hematocrit , blood pressure , hemoglobin , hemoconcentration , medicine , heart rate , central venous pressure , anesthesia
We tested the hypothesis that erythrocyte count (RBC), hemoglobin (Hgb), and hematocrit (Hct) would be similar during lower body negative pressure (LBNP) and graded blood loss (BL) in humans. Arterial blood pressure, central venous pressure and heart rate were measured in 12 healthy males (88 ± 3 kg) during LBNP and BL. The LBNP protocol consisted of 5 min stages at 0,‐15, ‐30, and ‐45 mmHg. The BL protocol consisted of removal of three 333 mL aliquots of blood (1 L total) which was stored for reinfusion. RBC, Hgb, and Hct were obtained via arterial catheter at baseline and at the end of the final stage for both LBNP and BL. There were no differences (P > 0.05) in baseline values between treatment groups for RBC, Hgb, or Hct. RBC (4.81 ± 0.10 to 4.97 ± 0.10 10 12 /L), Hgb (14.18 ± 0.39 to 14.68 ± 0.36 g/dL), and Hct (40.88 ± 0.82 to 42.36 ± 0.83 %) increased from baseline to final stage (p<0.001 for all) during LBNP, while all values decreased from baseline to final stage (p<0.015 for all) during BL (4.82 ± 0.11 to 4.72 ± 0.11 10 12 /L; 14.33 ± 0.37 to 13.95 ± 0.39 g/dL; 41.09 ± 0.82 to 40.25 ± 0.86 %; respectively). The final stage values were greater in LBNP than BL for RBC, Hgb, and Hct (p< 0.001 for all). LBNP results in relative hemoconcentration while BL results in relative hemodilution. The clinical significance of these findings remains to be elucidated. Grant Funding Source : Supported by U.S. Army MRMC Combat Casualty Care Research Program Grant # W81XWH‐11‐1‐0823.