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The impact of cycling in a hot environment on cytokine release (705.2)
Author(s) -
Cherif Anissa,
Knez Wade,
Farooq Abdulaziz
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.705.2
Subject(s) - c reactive protein , inflammation , cycling , chemistry , medicine , cytokine , interleukin 6 , interleukin , endocrinology , zoology , biology , archaeology , history
The objective of this study was to determine the effect of hyperthermic environment in combination with exercise on the plasma concentration of interleukin‐1ra (IL‐1ra), interleukin‐6 (IL‐6) and C‐reactive protein (CRP), compared with exercise in a neutral condition. Nine recreational volunteers cycled in two different environmental conditions (neutral (24⁰C, 30⁰C) and hot (35⁰C, 70⁰C). Blood samples were collected before, during and after exercise (0, 10, 25, 35, 45, 55 and 65 min) to determine indirect markers of inflammation. ELISA determined the concentration of cytokines and CRP. Overall, the production of IL‐1ra was significantly higher in the hot condition (216.5±71.9 µg/ml) compared to neutral (198.3±49.5 µg/ml) (P=0.003) and increased with time (P=0.009). Similarly there was a significant effect of condition (P<0.001), IL‐6 in hot condition (663.9±270.4 µg/ml) was greater than neutral (499.5±127.8 µg/ml) and CRP in the hot condition (565.2±252.3 ng/ml) was higher than neutral (405.7±221.8 ng/ml) (P<0.001). There were significant effect of time on IL‐1ra (P=0.009) and IL‐6 (P=0.013) but not CRP. Initial analysis suggests that exercising in hyperthermic conditions increase IL‐6, which stimulates the production of the anti‐inflammatory properties of IL‐1ra and CRP.