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Central actions of hydrogen sulfide (703.1)
Author(s) -
Yosten Gina,
Samson Willis
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.703.1
Subject(s) - sodium hydrosulfide , hydrogen sulfide , corticosterone , gastrointestinal tract , hormone , chemistry , in vivo , prolactin , central nervous system , endocrinology , medicine , saline , biology , biochemistry , sulfur , microbiology and biotechnology , organic chemistry
Hydrogen sulfide (H2S) is a novel gaseous signaling molecule that has been shown to exert multiple beneficial effects in vivo, including anti‐inflammatory actions and protective effects in the gastrointestinal tract. HS converting enzymes are produced in the central nervous system, and thus may exert important actions in brain. We therefore tested the ability of HS to modulate mean arterial pressure, fluid intake, and stress hormone secretion in adult, male rats, via intracerebroventricular (icv) injection H2S donors (sodium hydrosulfide hydrate). Central administration of H2S donors led to rapid, transient, dose‐related increases in mean arterial pressure in conscious, freely moving male rats, but did not alter water or saline intakes. Furthermore, injection of H2S donors led to an increase in plasma corticosterone levels, but not plasma prolactin levels, in non‐stressed animals. From these data, we conclude that H2S may act as an important signaling molecule in brain, although elucidation of the physiological relevance of this gaseous messenger requires further evaluation.