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Influences of gender, age, and ethnicity on nitric oxide and cGMP concentrations biocaptured over acupoint/meridians: analysis in fifty‐nine human subjects (698.7)
Author(s) -
Ma ShengXing,
Li XiYan,
Jiang Isabelle,
Hu Jay,
Lee Paul
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.698.7
Subject(s) - meridian (astronomy) , nitric oxide , endocrinology , medicine , astronomy , physics
The purpose of this study was to determine the influence of gender, age, and race on nitric oxide (NO)‐cGMP concentrations over acupuncture points (acupoints), meridian lines between acupoints, and non‐meridian controls in healthy volunteers. A biocapture device was taped onto the skin surface along the Pericardium (PC) and Lung (LU) acupoints/meridian located on the arm, and the Bladder (BL) acupoints/meridian on the leg in 59 subjects. Total nitrate and nitrite (NOx¯) and cGMP levels in the biocaptured samples were measured using chemiluminescence and ELISA, respectively. Results show that cGMP concentrations over the PC acupoints and non‐meridian area are higher in females than males, but NO concentration over the region is modified by body weight, which contain more subjects with obesity in man. NO and cGMP levels along the BL meridian are increased in middle age/elder subjects compared to adolescent/adult subjects but not over PC regions. There was no detectable significance between NO nor cGMP concentrations among racial groups studied. Our findings suggest that different NO and cGMP levels between genders and age groups are influenced by sympathetic activity, body weight, hormones, sweat rates, and skin thickness. Enhanced NO and cGMP levels along the BL meridian and bladder dysfunction in aged subjects requires investigation. Grant Funding Source : Supported by NIH AT002478 and Oppenheimer Seed Grant to S. Ma