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Sustained Resveratrol infusion increases renal blood flow without changing glomerular filtration rate in normal rat (692.1)
Author(s) -
Gordish Kevin,
Beierwaltes Wiliam
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.692.1
Subject(s) - resveratrol , renal function , renal blood flow , chemistry , dilator , endocrinology , medicine , nitric oxide , vascular resistance , hemodynamics , biochemistry
The polyphenol resveratrol has cardiovascular benefits, but it’s effect on renal hemodynamics and glomerular filtration rate (GFR) remain unknown. Resveratrol vasodilates by increasing nitric oxide (NO), may inhibit reactive oxygen species (ROS), and prevent ROS depletion of NO. We found an acute bolus of resveratrol transiently increased renal blood flow (RBF) and decreased renal vascular resistance (RVR). We hypothesized a sustained infusion of resveratrol may increase RBF, and therefore GFR. We infused vehicle for 30 minutes followed by resveratrol infusion (30 minutes) at of 0, 0.5, or 1.0 mg/min. We measured RBF, calculated RVR and measured GFR with FITC‐inulin. 1.0 mg/min resveratrol infusion increased RBF by 15%, from 7.17±0.40 to 8.25±0.40 ml/min/gkw ( p <0.01, n =7). RVR decreased from 13.61±0.85 to 11.81±1.01 ARU ( p <0.04). GFR remained unchanged (1.61±0.17 vs. 1.68±0.20 mg/min/gkw, respectively). In separate experiments, control RBF was unchanged with 0.5 mg/min resveratrol (7.69±0.84 vs. 7.88±0.94 ml/min/gkw, n =9). RVR was also unaffected. Control GFR was 0.98±13 ml/min/gkw remained unchanged by resveratrol (1.12±0.22 ml/min/gkw). We conclude that a constant infusion of resveratrol induced a significant increase in RBF and decreased RVR while not changing GFR, suggesting uniform dilator effects on both afferent and efferent resistance vessels. Grant Funding Source : supported by NIH 5P01HL090550‐04