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Curcumin ameliorates nephrotoxicity and histopathological alterations induced by chlorpyrifos in albino rats (690.5)
Author(s) -
AlAmoudi Wael
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.690.5
Subject(s) - curcumin , nephrotoxicity , creatinine , kidney , blood urea nitrogen , oxidative stress , glycogen , endocrinology , chlorpyrifos , medicine , toxicity , chemistry , pharmacology , biology , pesticide , agronomy
In the present investigation an attempt was made to assess the possible ameliorative role of curcumin on nephrotoxicity and histopathological alterations caused by Chlorpyrifos in the kidney tissue of albino rats. Rats were given daily doses of intragastric and suble‐ thal concentrations of CPF. Histological examination showed alterations in the treated kidney such as degeneration of the renal tubules, atrophy and hypertrophy of glomeruli and intertubular leucocytic infiltrations. The histopathological changes were more pro‐ nounced with higher concentrations of CPF. The degree of degeneration of renal tubules found in higher concentration treatment of CPF was more pronounced. These alterations of the renal tubules and glomeruli affected the functioning of motor coordination of the rat body. Moreover, histochemical examination of the renal tubules showed depletion of glycogen and total proteins content and marked elevation in serum creatinine and blood urea nitrogen. However, treating animals with CPF and curcumin (150 mg/kg b. w. 5 days / week for 6 weeks) caused an improvement in histological and histochemical appearance of the kidney together with decrease of serum creatinine and blood urea nitrogen. It is concluded from the obtained results that CPF is highly toxic to albino rats by causing nephrotoxicity and may leads to oxidative stress. This effects appeared to be prevented and ameliorated by curcumin.