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Anti‐inflammatory effects of Hedyotis diffusa in ob/ob mice (688.2)
Author(s) -
Kang MinJung,
Kim JungIn,
Yim JungEun
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.688.2
Subject(s) - insulin resistance , proinflammatory cytokine , fatty liver , oxidative stress , medicine , leptin , inflammation , endocrinology , insulin , obesity , disease
Non‐alcoholic fatty liver disease (NAFLD) is the most common liver disease and is associated with insulin resistance, oxidative stress, and inflammation. Insulin resistance might play an important role in the pathogenesis of NAFLD. Proinflammatory cytokines are thought to be associated with the development of insulin resistance. It has been reported that Hedyotis diffusa was effective at improving insulin resistance and fatty liver in an animal model. This study investigated the anti‐inflammatory effects of Hedyotis diffusa in leptin‐deficient ob/ob mice. Five week‐old ob/ob mice (C57BL/6J, n=16) were fed AIN‐93G diet or diet containing 1% fermented alcohol extract of Hedyotis diffusa for 8 weeks. The serum TNF‐α, IL‐6, and monocyte chemotactic protein‐1 (MCP‐1) levels were measured using enzyme‐linked immunosorbent assay (ELISA) kits. Body weight and food intake of the Hedyotis diffusa group were not significantly different from those of the control group. The serum TNF‐α level of the Hedyotis diffusa group was significantly lower than in the control group. Hedyotis diffusa extract supplementation reduced the serum IL‐6, as compared to the control group. The serum MCP‐1 levels were significantly reduced by the consumption of Hedyotis diffusa extract. Therefore, Hedyotis diffusa could be beneficial for alleviating NAFLD by reducing inflammation. Grant Funding Source : This research was supported by NRF in Korea (20100011980)