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Postoperative cognitive dysfunction depends on the type of surgery (684.6)
Author(s) -
Hovens Iris,
Schoemaker Regien,
Zee Eddy,
Leeuwen Barbara
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.684.6
Subject(s) - postoperative cognitive dysfunction , medicine , cardiac surgery , abdominal surgery , morris water navigation task , sham surgery , cognition , superior mesenteric artery , anesthesia , ischemia , artery , effects of sleep deprivation on cognitive performance , cognitive flexibility , cardiology , surgery , pathology , psychiatry , alternative medicine
The risk of postoperative cognitive dysfunction (POCD) is higher after cardiac surgery compared to non‐cardiac surgery. The objective of this study was to compare POCD after cardiac and non‐cardiac surgery in rats as tool to study the underlying mechanisms. Male Wistar rats received abdominal surgery with ischemia‐reperfusion (i.r.) of the upper mesenteric artery (A‐S, n=12) or cardiac surgery with i.r. of the left coronary artery (MI‐S, n=12). Controls remained naive (C: n=12), received only anesthesia (A: n=12) or sham thorax surgery (T‐S, n=12). Weight loss accounted for severity of surgery. On postoperative day 10 to 14, cognition was assessed in the novel object and location test and Morris water maze (MWM). Location recognition was impaired in A‐S and MI‐S. Only A‐S displayed impaired spatial memory in the MWM, whereas only MI‐S displayed impaired object recognition and cognitive flexibility in the MWM. T‐S or A did not cause any cognitive impairment. All surgical procedures induced weight loss. MI‐S lost more weight than A‐S. Abdominal surgery only impaired spatial cognition, whereas cardiac surgery led to a more generalized cognitive dysfunction, indicating POCD depends on the type of surgery. Analysis of (neuro)inflammatory markers may reveal the basis of these findings and thus provide valuable insight in the mechanisms underlying POCD.