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mTOR inhibition increases learning/memory (684.16)
Author(s) -
Donnelly Ginger,
Goyal Ravi
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.684.16
Subject(s) - pi3k/akt/mtor pathway , memory impairment , morris water navigation task , spatial learning , neuroscience , memory improvement , psychology , cognition , mtorc2 , medicine , biology , signal transduction , microbiology and biotechnology , mtorc1
Cognitive impairment is a far too common medical problem. Moreover, there is no effective therapy for increasing memory and learning in individuals with such an impairment. Recent studies implicate that mTOR pathway may be involved in learning and behavior. Thus, we tested the hypothesis that mTOR inhibition can increase the learning and memory in mice. We examined spatial learning ability in mTOR heterozygous and control mice by Morris Water Maze. In the control group of mice, we also inhibited mTOR pathway by rapamycin administration and examined its effect on learning and memory.Our results demonstrate that mTOR heterozygous mice had significantly higher ability for spatial learning. Also, inhibition of mTOR in control mice increased the spatial learning ability. We conclude that mTOR inhibition can lead to increased learning ability. However, further investigations are needed to examine the role of mTOR in Alzheimer and disorders in which memory impairment is the major pathology.