Premium
Antidepressant‐like effects after chronic treatment with zinc chloride (684.14)
Author(s) -
Seara Fernando,
LaureanoMelo Roberto,
Novais Renata,
Araujo Iracema,
Almeida Claudio,
Conceicao Rodrigo,
Reis Luis,
Silva Alba,
Cortes Wellington
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.684.14
Subject(s) - medicine , endocrinology , chemistry , zinc , open field , corticosterone , behavioural despair test , saline , elevated plus maze , anxiolytic , zinc deficiency (plant disorder) , antidepressant , hippocampus , hormone , anxiety , receptor , organic chemistry , psychiatry
This study aimed to elucidate, for the first time, the effects of chronical oral treatment with zinc chloride on the depressant‐like behavior of Wistar rats and correlate them with the neuroendocrine profile promoted by our protocol. Two groups of male Wistar rats (200‐250 g) were treated with zinc chloride (15 mg/kg n=16) or isotonic saline (n=17) during 30 days. The rats were kept in a controlled room temperature with light/dark cycle and food ad libitum. After the treatment, both groups were submitted to a behavioral assessment in an open field (OF), elevated plus maze (EPM) and forced swim (FS) test for five minutes. Moreover, basal plasma corticosterone, triiodothyronine (T3), thyroxine (T4) were measured. Also, iodothyronine deiodinase type 2 (Dio2) activity in brown adipose tissue (BAT) and hippocampus were assessed. In view of our results, chronic treatment with orally zinc chloride does not alter the spontaneously locomotor activity as assessed by OF. However, zinc‐treated group showed anxiolytic effects as shown by less time of grooming (P<0,05), even though the episodes of grooming did not differ between groups. Corroborating the aforementioned anxiolytic effects on OF, zinc treatment reduced the time spent in closed arms (P<0,01) and the number of fecal pellets (P<0,05) on EPM. Yet, zinc‐treated group showed fewer immobilization time compared to control group on FS (P<0,05). Regarding to neuroendocrine profile, zinc‐treated group showed higher plasmatic T3 (P<0,01), however there were no differences on serum corticosterone and T4. Furthermore, there were no differences on Dio2 activity on BAT and hippocampus. We can conclude that chronically treatment with orally zinc chloride provides antidepressant‐like effects and discrete anxiolytic‐like effects during adulthood, presumably by raising plasma T3 level with no involvement of Dio2, taking into account that rodents with signs of depression‐like behavior often present hypothyroidism. Grant Funding Source : FAPERJ/CNPq