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Interaction of ApoE genotype, antioxidants and exercise on brain function (684.12)
Author(s) -
Chaudhari Kiran,
Wong Jessica,
Vann Philip,
Sumien Nathalie
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.684.12
Subject(s) - apolipoprotein e , context (archaeology) , regimen , antioxidant , medicine , disease , flexibility (engineering) , affect (linguistics) , genotype , psychology , physiology , physical therapy , endocrinology , biology , paleontology , biochemistry , statistics , mathematics , communication , gene
Increased risk of developing Alzheimer’s disease (AD) has been associated with the presence of the ε4 allele of apolipoprotein E (ApoE). To reduce brain dysfunction, a healthy lifestyle, such as daily exercise and healthy eating habits, is often recommended. Though both interventions have shown promising results individually, it remains unknown whether their concurrent implementation will lead to a synergistic/additive effect or an antagonistic interaction nullifying their beneficial effects in the context of ApoE genotype and AD risk. Our study aimed at determining the nature of the interaction between a moderate exercise regimen and antioxidant supplementation on functional outcomes in a mouse model of increased AD risk. Male and female mice (12‐13 month old), expressing the human ApoE3 or E4, were placed under one of the treatments: Sedentary/Control diet (SedCon), Sedentary /Antioxidant‐rich diet (Vitamins E and C; SedEC), Exercise/Control diet (ExCon), Exercise/ Antioxidant‐rich diet (ExEC), for 8 weeks prior to and throughout behavioral testing. The ApoE3 mice performed better than the ApoE4 ones on a test for coordinated running. Only the ExEC treatment improved the performance of the mice, however only of the male ApoE3. In a test for spatial learning and memory, all treatment improved the performance of the ApoE4 mice but not the ApoE3. In the active avoidance test, Ex and EXEC treatments improved performance in ApoE3 mice during acquisition and improved cognitive flexibility but did not affect the performance of the ApoE4 mice. These preliminary data indicate that genotype and sex may be critical determinants in the functional outcomes of interventions such as exercise and antioxidants. There also was no evidence of either a synergistic or antagonistic interaction between the two treatments.