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Cordyceps sinensis Cs‐5 improves memory and learning abilities in a dysmnesia model (684.1)
Author(s) -
Dong Yunzi,
Yang Jieying,
Zhang Yan,
Zhao Chunsheng,
Wu Zimei,
Tan Ningzhi,
Lu Jihong,
Bartlett Mark,
Zhu Jiashi
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.684.1
Subject(s) - cordyceps , morris water navigation task , memory impairment , water maze , medicine , pharmacology , latency (audio) , chemistry , psychology , traditional medicine , hippocampus , neuroscience , cognition , computer science , telecommunications
Cordyceps sinensis Cs‐5, a mycelia fermentation product of Cordyceps sinensis (Cs), has shown its health benefits in modulating immune functions and enhancing sexual functions. This study was to examine the effects of Cs‐5 on improving memory and learning abilities in a mouse model with memory impairment. ICR male mice (2 months) were randomized into 3 groups on the basis of the pre‐study swimming latency in water maze test, and received Cs‐5 at a dose of 0.5 or 1.5 g/kg, or vehicle for 60 days. The mice received intraperitoneal injection of Scopolamine Hydrobromide at a dose of 5mg/kg for memory acquisition impairment, and were tested with water maze and step‐through tests to evaluate the memory and learning abilities. Compared to controls, mice received Cs‐5 at a dose of 0.5 g/kg (equivalent to the human recommended dose) showed significantly shortened swimming latency in water maze test, and significantly prolonged step‐through latency in step‐through test (both p=0.03). In conclusion, our results indicate that Cs‐5 is effective on improvement of memory and learning abilities in a mouse model with memory impairment, supporting its potential anti‐aging effect.