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Evaluation of the respiratory and cardiovascular activities in juvenile rats submitted to sino‐aortic denervation (681.9)
Author(s) -
Amorim Mateus,
Bonagamba Leni,
Souza George,
Moraes Davi,
Machado Benedito
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.681.9
Subject(s) - medicine , respiratory system , anesthesia , expiration , baroreflex , denervation , respiratory frequency , mean arterial pressure , blood pressure , cardiology , heart rate , tidal volume
Rats submitted to sino‐aortic denervation (SAD) present normal basal sympathetic activity and mean arterial pressure (MAP) few days after the surgical procedure. In the present study, we evaluated the cardiovascular and respiratory changes 3 and 10 days after SAD. Male juvenile Wistar rats were submitted to SAD or sham surgery and four groups were evaluated 3 (SAD and Sham) and 10 days (SAD and Sham) after the surgery. Cardiovascular and respiratory parameters were recorded in awake rats and the arterial baroreflex was tested to verify the efficacy of SAD. It was observed that MAP in all experimental groups was similar. The variability of MAP was significantly higher in SAD than in Sham rats at 3 (4.63±0.27 vs 2.86±0.16 mmHg) and 10 days (5.68±0.56 vs 2.68±0.18 mmHg). No major changes in the respiratory parameters were observed in SAD at 3 days after the surgery, but the respiratory frequency (114±4 vs 136±5 cpm) and minute volume (1457±67 vs 1998±165 mL/Kg/min) were significantly reduced 10 days after SAD. The durations of expiration (0,34±0,01 vs 0,27±0,01 sec), inspiration (0,22±0,01 vs 0,19±0,01 sec) and respiratory cycle (0,56±0,02 vs 0,46±0,02 sec) were significantly increased 10 days after SAD. These data suggest that 10 days after SAD changes in the respiratory pattern may contribute to the modulation of the sympathetic activity and prevent major changes in MAP in SAD rats. Grant Funding Source : Supported by FAPESP, CAPES and CNPq