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Hydrogen sulphide acts in the subfornical organ and paraventricular nucleus to increase blood pressure (681.6)
Author(s) -
Smith Pauline,
Ferguson Alastair
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.681.6
Subject(s) - subfornical organ , microinjection , forebrain , medicine , endocrinology , central nervous system , median preoptic nucleus , chemistry , blood pressure , angiotensin ii
Hydrogen sulfide (H 2 S) is as an endogenous gaseous transmitter that has been shown to act in the central nervous system to influence variety of functions including cardiovascular function. Administration of H 2 S in the lateral ventricle has been shown to increase blood pressure although the specific nuclei responsible for mediating these effects have not been identified. The subfornical organ (SFO) in the forebrain and the hypothalamic paraventricular nucleus (PVN) are central nervous system structures with well‐documented roles in cardiovascular regulation. The present study was undertaken to determine the effects of direct administration of the hydrogen sulfide donor, sodium hydrogen sulfide (NaH 2 S),into the SFO and PVN in urethane anesthetized male Sprague Dawley rats. Microinjection of NaH 2 S (10mM, 0.5µl) into either the SFO or PVN resulted in increases in BP (SFO mean AUC = 663.3 ± 51.6 mmHg*s, n=5; PVN mean AUC 447.4 ± 66 mmHg*s, n=4) and HR (SFO mean AUC = 29.6 ± 5.9 beats, n=5; PVN mean AUC 10.7 ± 2.1 beats, n=4). These cardiovascular responses were of rapid onset (responses began within 10s of microinjection) and short duration, returning to baseline within 90s. In both cases, these responses were shown to be dose related and site specific. These observations identify the SFO and PVN as possible central nervous system locations at which H 2 S may act to influence cardiovascular regulation.