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Coronary ischemia increases corticotropin releasing hormone receptor expression in locus coeruleus of female rats (680.5)
Author(s) -
Scrogin Karie,
Lawrence Flora,
Samarel Allen,
Koshman Yevgeniya
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.680.5
Subject(s) - locus coeruleus , medicine , endocrinology , forebrain , norepinephrine , receptor , adrenergic receptor , corticotropin releasing hormone , neurotransmission , tyrosine hydroxylase , adrenergic , central nervous system , dopamine
Women with coronary artery disease have two times the rate of anxiety as men, and anxiety is a better predictor of future cardiovascular events in women than men. We found that coronary artery ligation (CAL) impairs memory of fear extinction in female, but not male rats. Αdrenergic receptors in the forebrain regulate fear expression and extinction. The locus coeruleus (LC) is the sole source of norepinephrine in cortical and subcortical regions that govern fear expression. Our evidence suggests that adrenergic neurotransmission in the female rat cortex is increased after CAL. The corticotropin releasing hormone receptor, CRF1, stimulates LC activity during stress. Here, we examined the density of CRF1 in tyrosine hydroxylase‐positive LC neurons in male and female rats 8 weeks after CAL. Females showed a higher percentage of LC cells with high density CRF1 label (p<0.05). CAL surgery further increased high density CRF1 label in females (p<0.05). The percentage of LC neurons with high density CRF1 was inversely correlated with fractional shortening in females (p<0.05), but not males. Increased CRF1 expression may contribute to elevated cortical adrenergic neurotransmission after CAL in females.