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Sympathetic reactivity in young women with a family history of hypertension (680.11)
Author(s) -
Greaney Jody,
Kaiser Christopher,
Matthews Evan,
Wenner Megan
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.680.11
Subject(s) - blood pressure , medicine , isometric exercise , endocrinology , family history , cold pressor test , cardiology , heart rate
Young adults with a family history of hypertension (+FH) have an increased risk of developing hypertension. Further, the blood pressure (BP) response to sympatho‐excitatory stimuli in young adults can predict the future development of hypertension. Therefore, we hypothesized young women +FH (n=7, 22±1 yrs, 21±1 kg/m 2 , 81±2 mmHg resting mean BP) will have exaggerated sympathetic reactivity compared to young women without a family history of hypertension (‐FH; n=9, 23±2 yrs, 22±1 kg/m 2 , 80±2 mmHg resting mean BP). BP and muscle sympathetic nerve activity (MSNA) were measured during three sympatho‐excitatory maneuvers: 2 min of isometric handgrip exercise at 30% of maximal voluntary contraction (EX), 3 min of post‐exercise ischemia (PEI), and a cold pressor test (CPT). The increase in BP was greater in +FH during the last minute of EX ( ΔMean BP: +FH 19±3 vs. ‐FH 11±2 mmHg, P =0.03) and during PEI ( ΔMean BP: +FH 14±3 vs. ‐FH 6±1 mmHg, P =0.03) . The increase in MSNA was greater in +FH during EX (ΔMSNA: +FH 15±4 vs. ‐FH 8±2 burst/min, P =0.13) and PEI (ΔMSNA: +FH 15±2 vs. ‐FH 5±2 burst/min, P <0.01). In a subset of women (+FH n=6, ‐FH n=5), +FH tended to have a greater increase in BP during CPT ( ΔMean BP: +FH 12±2 vs. ‐FH 8±2 mmHg, P =0.21), but ΔMSNA was not different ( P >0.05). These preliminary data suggest that +FH women may have greater sympathetic reactivity compared to ‐FH women.