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Altered skin vasomotion in hypertensive humans (677.1)
Author(s) -
Bruning Rebecca,
Kenney W.,
Alexander Lacy
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.677.1
Subject(s) - vasomotion , medicine , nitric oxide , vasodilation , endocrinology , laser doppler velocimetry , endothelial dysfunction , endothelium , cardiology , blood flow
Endothelium‐dependent cutaneous vasodilation (VD) is attenuated in essential hypertensive (HTN) humans. Using spectral analysis (fast Fourier transformation) we aimed to characterize vasomotion in laser Doppler flowmetry (LDF) recordings during local heating (LH)‐induced VD before and after inhibition of nitric oxide (NO)‐dependent signaling (NOS‐I: L‐NAME) in HTN and normotensive (NTN) humans. We hypothesized that HTN would have lower total power spectral densities (PSD), and in the frequency intervals (FI) associated with endothelial and neurogenic vascular control. LDF recordings during LH experiments from 18 HTN (MAP: 108±2mmHg) and 18 NTN (MAP: 88±2mmHg) men and women were analyzed. LH‐induced VD increased total PSD for all FI (all p<0.001). HTN had a lower total PSD (HTN:30±6AU 2 , NTN:14±3AU 2 , p=0.03) and neurogenic FI (HTN:6±1AU 2 , NTN:17±3AU 2 , p<0.01) versus NTN. As a percentage of total PSD, HTN had reduced neurogenic (HTN:41±3%, NTN:51±1%, p<0.001) and higher myogenic contributions (HTN:29±3%, NTN:24±1%, p=0.04) to the total spectrum. NOS‐I decreased total PSD (p<0.001) for both groups, but HTN exhibited lower endothelial (p<0.01), neurogenic (p<0.05), and total PSD (p<0.001) compared to NTN. These data suggest that HTN results in altered neurogenic and NO‐dependent control of skin vasomotion and support the use of spectral analysis as a non‐invasive technique to study vasoreactivity. Grant Funding Source : Supported by R01‐HL093238‐02