Effects of stenosis on hemodynamics in carotid artery bifurcation using 2D MR‐imaging computational fluid dynamics: simulated versus real cases (671.4)

Carotid artery stenosis is one of major risks of stroke. Magnetic resonance (MR) imaging combined with computational fluid dynamics becomes a powerful tool to investigate hemodynamic changes in circulatory system for specific patients. In this study, hemodynamics obtained from a real stenotic model of carotid artery from two patients was compared with a simulated stenotic model from two healthy subjects. MR angiographic image of carotid artery was reconstructed as an input geometry for two‐dimensional computational fluid dynamics. Inlet velocity used in the calculation was obtained from Doppler ultrasound measurement. This calculation was based on the simple assumptions i.e. incompressible and Newtonian fluid, rigid vascular wall and non‐slip condition at wall. The computational results showed that stenosis in common carotid artery increased blood flow velocity in internal carotid artery which was higher than that in external carotid artery. Increased severity of stenosis also enhanced blood flow velocity but lowered wall shear stress on the inner wall of internal carotid artery. Multiple stenotic points decreased velocity of internal carotid artery compared with single point stenosis. This study demonstrated that the simulated stenotic model of carotid artery from healthy subjects has conditionally used to represent the effects of stenosis found in the real stenotic model. Grant Funding Source : Supported by Facualty of Medicine, Prince of Songkla University and NSTDA