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Effect of non‐contingent ethanol administration on self‐administration of ethanol in cynomolgus macaques (658.7)
Author(s) -
Allen Daicia,
Helms Christa,
Grant Kathleen
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.658.7
Subject(s) - ethanol , self administration , saline , zoology , medicine , anesthesia , chemistry , toxicology , biology , biochemistry
After chronic ethanol self‐administration animals show decreased variability in daily drinking, suggesting titration of dose. Previous studies found that self‐administration with limited access to ethanol was resistant to experimenter‐administered ethanol, resulting in intake of a greater‐than‐average daily dose. The current study examined the effects of ethanol gavage on daily intake with continuous access. Ten adult male cynomolgus macaques were induced to drink 4% (w/v) ethanol using a schedule‐induction procedure, followed by 22 hours/day continuous access to ethanol and water. Meals were given 3 times per day at 0, 2, and 4 hours after session start. After 6 and 12 months of daily access, animals were placed in a primate chair and administered ethanol (1.0 g/kg and 1.5 g/kg, i.g.) or saline (i.m.) 2 hours before a daily session. After 6 months of ethanol consumption, there was a robust dose‐dependent decrease in drinking after the challenges ( p <0.001), indicating that dose was titrated. Interestingly, at the 12‐month time point, drinking behavior was resistant to the pretreatment, and significant differences from saline were only observed in the 1.5g/kg dose ( p <0.05). The dose of self‐administered ethanol was not correlated with blood ethanol concentration after i.g. ethanol, measured immediately before the session. These data suggest that extended access to ethanol self‐administration in monkeys results in intakes that are less sensitive to pharmacological feedback. Grant Funding Source : Supported by AA013510 (Grant)