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The study of anti‐aging of Zishen Yigan Wan in vivo and vitro (657.2)
Author(s) -
Liu Ying,
Liu Ming,
Wang Xuanbin,
Li Hongliang,
Zhang Qiufang,
Zhang Xiaoyan,
Wang Linhai
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.657.2
Subject(s) - in vivo , oxidative stress , medicine , pharmacology , immune system , antioxidant , spleen , traditional medicine , immunology , chemistry , biology , biochemistry , microbiology and biotechnology
The aging‐associate diseases result in greater and greater burden for the families and community in China. A traditional folk formulation, Zishen Yigan Wan comprises 11 traditional Chinese medicinal herbs. This study aimed to observe the effects of Zishen Yigan Wan on anti‐aging and the underlying mechanisms in vivo and in vitro. Compared with the model group of ICR mice, the escape latency of each group treated by Zishen Yigan Wan with low, medium and high dosage decreased significantly ( P <0.01), and the number of passing though the original platform increased significantly ( P <0.01); the thymus, spleen index, GSH‐PX activity of liver, SOD activity of plasma, liver and brain tissue increased significantly, respectively ( P <0.01); while the MDA level of the liver and brain, the level of NO in plasma dropped significantly ( P <0.01); The viability of PC12 cells pretreated with Zishen Yigan Wan at low, medium and high dosage were increased significantly ( P <0.01). The studies showed that Zishen Yigan Wan could delay ICR mice aging induced by D‐galactose, and improve the ability of learning and memory and immune function of aging mice. The mechanism may be that Zishen Yigan Wan could clear away free radicals and improve the antioxidant system’s activity of the body to slow down the oxidative stress damage of the body induced by D‐galactose. Grant Funding Source : Supported by 2011 Project of Hubei Province, NO. 4