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Antibacterial activities of a novel silver(I) complex with furosemide (654.8)
Author(s) -
Cóssia Silva Maria,
Lazarini Silmara,
De Carvalho Renata,
Amaral André,
Corbi Pedro,
Lustri Wilton
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.654.8
Subject(s) - silver sulfadiazine , antibacterial activity , pseudomonas aeruginosa , staphylococcus aureus , chemistry , furosemide , escherichia coli , microbiology and biotechnology , medicine , biology , bacteria , biochemistry , organic chemistry , surgery , wound healing , genetics , gene
The use of metal complexes in medicine dates back to the 16th century. Nowadays one of the best examples of a metal‐based drug used in medicine is silver‐sulfadiazine (SSD). This compound is used topically as a cream in the treatment of burns and wounds preventing the appearance of skin bacterial infections. Due to the fact that several metal complexes are extensively applied in the treatment of various diseases the knowledge and understanding of their chemical and pharmacological properties are of high significance. The present research aims to establish conditions for the synthesis and evaluation of the antibacterial activities of a novel silver complex with furosemide (Ag‐fur). Elemental analysis of C, H and N showed a 1:1 metal/ligand composition for the complex, with the molecular formula AgC12H10ClN2O5S. Although insoluble in water, the Ag‐fur complex is soluble in dimethyl sulfoxide. The antibacterial activities of the complex were primarily evaluated by antibiogram assays using the disc diffusion method. The Ag‐fur complex has shown to possess significant antibacterial activity against Staphylococcus aureus (Gram‐positive), Escherichia coli and Pseudomonas aeruginosa (Gram negative) when compared to AgNO3 and to the standard antibiotic ceftriaxone. Grant Funding Source : Supported by: Conselho Nacional de Desenvolvimento Científico e Tecnológico ‐ CNPq