Premium
Garcinol attenuates TGF‐β1/Smad signaling in dimethylnitrosamine‐induced liver fibrosis (649.8)
Author(s) -
Cheng AnChin,
Lee MingFen,
Tsai ChenYu,
Li ChunI,
Pan MinHsiung
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.649.8
Subject(s) - smad , chemistry , aspartate transaminase , transforming growth factor , fibrosis , alanine transaminase , pharmacology , endocrinology , signal transduction , cancer research , medicine , biochemistry , enzyme , alkaline phosphatase
Garcinol is a polyisoprenylated benzophenone derivative from Garcinia indica and other related species. Many studies have shown that garcinol is a pleiotropic agent against inflammation. Our previous studies indicated that Garcinol supplementation alleviated the dimethylnitrosamine (DMN)‐induced liver damage, including the expression levels of alanine transaminase and aspartate transaminase and the histopathological status. In this study, we further investigate the effect of garcinol on the transforming growth factor‐β1 (TGF‐β1)/Smad signaling. Sprague‐Dawley rats were intraperitoneally given DMN (10 mg/kg) three days per week for four weeks. Garcinol (10 or 20 mg/kg) was administered by oral gavage daily. Hepatic tissue sections were stained for α‐smooth muscle actin (α‐SMA) and collagen I, and the hepatic TGF‐β1 expression was examined. Our results indicated that garcinol suppressed collagen deposition and α‐SMA formation in the DMN‐treated animals. These data demonstrated that garcinol attenuated TGF‐β1/Smad signaling in liver fibrosis. Grant Funding Source : Supported by Chang Jung Christian University Grant