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Iron biofortified beans improve iron status in Rwandan University women: results of a feeding trial (646.1)
Author(s) -
Haas Jere,
Luna Sarah,
Lung'aho Mercy,
Ngabo Fidel,
Wenger Michael,
MurrayKolb Laura,
Beebe Steve,
Gahutu JeanBosco,
Egli Ines
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.646.1
Subject(s) - anthropometry , hemoglobin , iron deficiency , ferritin , zoology , soluble transferrin receptor , biofortification , anemia , iron status , medicine , significant difference , analysis of variance , micronutrient , biology , pathology
Objective : To examine the efficacy of an iron biofortified bean intervention on iron status in iron depleted young women. Methods : 257 Rwandan university women (18‐27 y) with screening ferritin <20 μg/L were randomized to consume ~155 g/d, dry wt. of either iron biofortified beans (Fe=78 mg/g) or control beans (Fe=59 mg/g) per day for 135 days. Iron status (hemoglobin‐ Hb , ferritin‐ Fer , transferrin receptor‐ TfR , body iron‐ BI ), inflammation ( CRP, AGP ), and anthropometric indices were determined at enrollment, 7 random midpoints and after 135 days. Difference‐in‐difference analysis plus repeated measures ANOVA and linear and binomial regression models were used to evaluate the effect of the intervention on iron status. Results : At baseline, for the 231 study subjects who completed the study, 34% were anemic ( Hb <120 g/L), 73% had Fer <15.0 μg/L) and 48% had negative BI stores (Cook’s algorithm). After 135 days of feeding, there was significant group difference in change in Hb (difference=3.5 g/L, p<.001) and BI (difference=0.45 mg/kg, p=.033) in the high iron compared to control group. Also, 54 of 109 women with negative BI at baseline increased their BI by 1.5 mg/kg, with 30% more responders in the high iron compared to the control group. Conclusions : Consumption of iron‐biofortified beans over 4.5 months improved iron status in iron depleted Rwandan women. Grant Funding Source : HarvestPlus/IFPRI