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Breast milk carotenoid concentrations are decreased in obese mothers (645.5)
Author(s) -
Vishwanathan Rohini,
Panagos Patoula,
Sen Sarbattama
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.645.5
Subject(s) - zeaxanthin , lutein , carotenoid , breast milk , medicine , vitamin , gestational age , obesity , vitamin d and neurology , lycopene , vitamin a deficiency , pregnancy , endocrinology , physiology , food science , retinol , chemistry , biology , biochemistry , genetics
Maternal obesity has been linked with poor neurodevelopmental outcomes in infants. We investigated the impact of maternal obesity on breast milk (BM) carotenoids. Subjects included 13 control/lean (Lc, mean BMI 21) and 9 obese (Ob, mean BMI 37) mothers who delivered healthy term babies (gestational age > 37 weeks). The study was approved by Tufts Medical Center IRB and informed consent was obtained from all subjects. BM and 3‐day diet records were collected between 6 and 10 weeks postpartum. BM was analyzed using standard lipid extraction and reverse phase HPLC. Carotenoid concentrations were lower in BM from Ob compared to Lc mothers. The differences were statistically significant for lutein, α‐ and β‐carotene. Adjusting for dietary intake did not alter the significance. Lutein, along with zeaxanthin, preferentially accumulates in the macular region of the retina and may influence visual development. The provitamin A carotenoids α‐carotene and β‐carotene provide a significant source of vitamin A for the BM‐fed infant. Insufficiency of these carotenoids in BM of Ob women may affect infant neurodevelopment.Carotenoids, nmol/L Lc (n=13) Ob (n=9)Lutein 75.33 (11.7) 33.5 (5.7)* Zeaxanthin 18.06 (3.53) 11.2 (1.71) Cryptoxanthin 58.99 (19.34) 15.66 (3.01) α‐carotene 16.6 (3.12) 4.25 (0.68)* β‐carotene 118.42 (24.26) 30.22 (4.36)* Lycopene 76.97 (17.78) 65.5 (13.26)Values are means (SE), * P <0.05 Grant Funding Source : Susan Saltonstall Grant Program, Department of Pediatrics,Tufts Medical Center