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Amino‐acid seric profiles in obese and normal women with normal non‐complicated pregnancies (643.9)
Author(s) -
CeballosAngeles Armida,
PrunedaPadilla Yunuen,
IbarraGonzález Isabel,
VelaAmieva Marcela,
VadilloOrtega Felipe,
VadilloOrtega Felipe,
PalaciosGonzález Berenice
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.643.9
Subject(s) - endocrinology , medicine , pregnancy , valine , leucine , obesity , amino acid , insulin resistance , gluconeogenesis , biology , metabolism , biochemistry , genetics
During normal pregnancy, metabolic change occurs leading to weight gain and insulin resistance. Obesity has been considered a metabolic disruptor that harms evolution of pregnancy, however few information is available to understand the mechanisms of damage of obesity in pregnancy. We decided to study amino acid profiles of obese women in order to obtain preliminary information comparing normal weight women along pregnancy. Women were selected according to pregestational BMI and two groups were analyzed: 1. BMI 蠄 24.9 (NWP) and 2. BMI 蠅30(OP). Results. Alanine concentrations were significantly higher in the second trimester and there was a significant increase in the gluconeogenic and ketogenic amino acid concentrations in OP group. Glucose concentration was significantly higher and there was an inverse correlation between leucine and valine with glucose concentrations in the OP group. A progressive decrease in the seric urea concentrations in the OP group was found. In conclusion, high levels of serum glucose in the OP group may be associated to increase channeling of aminoacids to gluconeogenesis derived from the reduction of oxidative degradation of these compounds. However, these striking changes related to the presence of increased adiposity coexisted with a normal pregnancy. A better knowledge of the limits of this metabolic plasticity may aid to identify specific changes associated to abnormal evolution of pregnancy.