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Obesity is associated with increased dihomo‐λ‐linolenic and with decreased nervonic and n‐3 fatty acids in plasma phospholipids (643.8)
Author(s) -
Pickens Charles,
Comstock Sarah,
Harris William,
Fenton Jenifer
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.643.8
Subject(s) - overweight , docosahexaenoic acid , medicine , eicosapentaenoic acid , endocrinology , obesity , waist , linoleic acid , body mass index , insulin resistance , fatty acid , polyunsaturated fatty acid , chemistry , biochemistry
Obesity and blood fatty acid (FA) levels are associated with inflammation and chronic disease risk. The purpose of this study was to identify associations between FA in plasma phospholipids (PPL) and body mass index (BMI). 126 Caucasian males (48‐65 years old) were categorized: lean (BMI<25), overweight (25蠄BMI<30), or obese (BMI蠅30). PPL were extracted and analyzed using a modified Rosen‐Folch method and gas chromatography. PPL from obese men were less likely to contain n‐3 FA compared to those from lean (OR 0.72). Specifically, PPL from obese men had lower content of linoleic acid (OR 0.79), docosahexaenoic acid (DHA) (OR 0.68), eicosapentaenoic acid (EPA) (OR 0.45), and EPA+DHA (OR 0.74). Nervonic acid (NA), an n‐9 FA, was less abundant in PPL from overweight (OR 0.24) and obese men (OR 0.13), while dihomo λ‐linolenic acid (DGLA), an n‐6 FA, was more abundant in PPL from overweight (OR 3.02) and obese (OR 3.70) men. DGLA was positively correlated and NA was negatively correlated with serum C‐peptide, an indicator of insulin resistance. Similar associations were observed when participants were stratified by waist circumference. Future studies should examine the potential role of NA and DGLA in obesity‐associated diseases. Grant Funding Source : Research Support: NIH R03CA142000 and MSU CTSI