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Quercetin‐rich onion peel extract of anti‐obesity in C57BL/6J mice fed a high fat diet (642.11)
Author(s) -
Bae ChoRong,
Moon Yeonjeong,
Jung Kevin,
Oh SukHeung,
Cha YounSoo
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.642.11
Subject(s) - quercetin , chemistry , adipose tissue , obesity , food science , endocrinology , medicine , biochemistry , biology , antioxidant
This study investigated the antiobesity effects of quercetin‐rich onion peel extract in C57BL/6J mice fed a high fat diet. Sixty male C57BL/6J mice aged 4 weeks were divided into 6 groups; ND (normal diet control), HD (high fat diet control 60% fat kcal), OPE‐L (High fat diet & Low dose Quercetin‐rich Onion peel extract), OPE‐H (High fat diet & High dose Quercetin‐rich Onion peel extract), QL (High fat diet & Low dose Quercetin), QH (High fat diet & High dose Quercetin). The amount of quercetin used in QL dose and QH dose was equivalent to the quercetin content in OPE‐L and OPE‐H doses respectively. The experiment was carried out for 14 weeks. The OPE‐L and OPE‐H groups has significantly decreased body weight gain, epididymal fat pad and gastrointestinal fat pad weights and liver TG, TC levels compared to the HD group, QL and QH groups. These results were supported by real time PCR analysis for mRNA expression of enzymes (SREBP‐1, PPARγ, PPARα, ACC, CPT1) related to lipid metabolism. These results indicate that quercetin‐rich onion peel extract might have an antiobesity effect on high fat diet‐ induced obese mice. (This work was supported by “Food Functionality Evaluation program” under the Ministry of Agriculture, Food and Rural Affairs and partly Korea Food Research Institute)