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Gender determines parameters of metabolic syndrome and inflammation (641.20)
Author(s) -
Ebron Kolin,
Missimer Amanda,
Freindenreich Daniel,
Volek Jeff,
Fernandez Maria Luz
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.641.20
Subject(s) - waist , dyslipidemia , medicine , metabolic syndrome , endocrinology , blood pressure , c reactive protein , inflammation , population , obesity , circumference , geometry , mathematics , environmental health
We recruited 8 men and 21 women (40‐75 y) with Metabolic syndrome (MetS) to evaluate whether gender was associated with specific parameters of MetS as well as low grade inflammation by measuring C reactive protein (CRP). Large waist Circumference (> 90 cm) was present in all women but not in all men. Similarly CRP values >3 mg/L were present in 50% of the women but not in all men. Women with the highest waist circumference (WC) (ranging from 103‐146 cm) also had the highest concentrations of CRP. More women presented the dyslipidemias associated with high triglycerides and low HDL while most of the men had elevated fasting plasma glucose and systolic blood pressure. For this population plasma HDL cholesterol (HDL‐C) was negatively correlated with weight (r= ‐0.485, P < 0.025), WC (r = ‐0.380, P < 0.05) and plasma triglycerides (r= 0.581, P < 0.0025). These results indicate that central adiposity in women is a major contributor to low grade inflammation and dyslipidemia while in men high blood pressure and fasting plasma glucose are major contributors to MetS and do not appear to be associated with visceral fat accumulation.