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Energy expenditure in obese and weight cycled mice (640.5)
Author(s) -
Chusyd Daniella,
Johnson Maria,
Smith Daniel,
Yang Yongbin,
Allison David,
Nagy Tim
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.640.5
Subject(s) - energy expenditure , energy balance , medicine , obesity , endocrinology , weight loss , caloric theory , cycling , fat mass , body weight , zoology , chemistry , biology , history , ecology , archaeology
Male C57BL/6J mice were used to investigate diet‐induced obesity with subsequent weight loss and regain (weight cycling – WC; n=9). Mice were ad libitum fed a high fat diet (45% cal from fat) from 2months until 24months of age (ever obese – EO; n=8), with a subset randomized at 11months of age to periodic caloric restriction and re‐feeding (WC). A full “weight cycle” was ~ 3.5months. Energy expenditure (EE) was measured at 17.5 and 24months of age after weight regain. There were no significant differences in body weight, fat mass, or lean mass between groups at either time point after weight regain, nor was there a significant difference in EE over time for either group (P>0.05). WC had a higher resting energy expenditure (REE) compared to the EO group at 24months of age when controlling for fat free mass (P=0.0257). WC may not affect EE as there were no differences between total energy expenditure, non‐resting energy expenditure, or respiratory exchange ratio at either time point, while the increased REE in the WC at 24months may indicate the animals were not yet in energy balance. Grant Funding Source : This study was supported in part by NIH grants R01AG033682, P30DK056336, P60DK079626, and T32HL10053