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Dietary fatty acid composition modulates parallel shifts in the metabolic profiles of mice and gut microbiota populations (637.7)
Author(s) -
Muller Catherine,
Walter Jens,
Chekal Jessica,
Peterson Daniel,
DiRusso Concetta
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.637.7
Subject(s) - gut flora , polyunsaturated fatty acid , food science , metabolism , feces , biology , biochemistry , composition (language) , chemistry , fatty acid , microbiology and biotechnology , linguistics , philosophy
Recent research showed that dietary fat impacts gut microbiota (GM) composition with consequences for host metabolism, particularly in the case of saturated fatty acids (SFA). However, little is known about the impact of other types of fatty acids (FA) on the interaction between GM and host. In this study, we evaluated the impact of diets enriched in health‐promoting polyunsaturated fatty acids (PUFA) or highly unsaturated fatty acids (HUFA) in comparison to SFA on host‐GM interactions. C57Bl/6 mice were placed on normal‐fat (7%) diets with the lipid portion enriched in one of the following: SFA, PUFA, HUFA, or a SFA/HUFA mixture. SFA increased body and liver weight, and liver triglycerides compared to the HUFA‐containing diets. HUFA resulted in the lowest amount of total liver FA and the highest amount of fecal excretion. In the liver, FA synthase and steroyl‐CoA desaturase expression was increased with SFA and PUFA compared to HUFA‐containing diets, while expression of Lipocalins 2 and 13 showed the opposite trend. In the gut, Bacteroides were significantly increased in the SFA/HUFA diet compared to the other three diets. Bifidobacteria were increased in the mice fed PUFA and HUFA‐enriched diets. In conclusion, dietary PUFA and, especially, HUFA enrichment resulted in beneficial changes in metabolic parameters and, speculatively, GM. Continuing research focuses on determining the relationship between the two. Grant Funding Source : Supported by University of Nebraska Agricultural Research Division Strategic Research Initiatives