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Variable iron status among twins and triplets at birth (636.3)
Author(s) -
Ru Yuan,
Pressman Eva,
Guillet Ronnie,
Cooper Beth,
Katzman Philip,
Caveglia Sarah,
O'Brien Kimberly
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.636.3
Subject(s) - medicine , birth weight , gestational age , fetus , soluble transferrin receptor , umbilical cord , obstetrics , pregnancy , cord blood , ferritin , gestation , percentile , hemoglobin , low birth weight , placenta , iron status , physiology , anemia , iron deficiency , biology , immunology , statistics , genetics , mathematics
Iron (Fe) uptake and transfer to the fetus is mediated by the placenta. The objectives of this study were to examine the degree of variability in neonatal Fe status between siblings born to women carrying twins or triplets and to investigate determinants of neonatal Fe status in this group. A total of 67 women carrying multiples aged 30.6 ± 5.2 were enrolled between the 1 st and 3 rd trimester of pregnancy. Maternal blood across pregnancy and umbilical cord blood at birth were utilized to assess neonatal Fe status including Hb, serum ferritin (SF), transferrin receptor (TfR), erythropoietin (EPO), and hepcidin. Neonates were born at week 34.5 ± 2.9 of gestation and weighed 2188 ± 613 g; 69% of neonates were preterm and 72% had low birth weight (LBW). Approximately 19% of neonates were anemic (Hb<13 g/dL) at birth, 27.3% had SF < 76 µg/L and 18% had TfR > 8.5 mg/L. Mean cord SF was 120 ± 82 µg/L (n=70); a value comparable to the 50 th percentile using normative data. Total body iron (TBI) in neonates was calculated using birth weight (kg), cord Hb (g/dL) and functional Fe in tissues as described by Georgieff et al with adjustment for gestational age at birth. TBI averaged 171 ± 27.3 mg per neonate at birth (n = 65) was significantly correlated to amnionicity (p = 0.0005). Ratio between maternal and neonatal TBI was 0.61 ± 0.1. Significant variability was evident in cord SF (n = 70, p = 0.0002), TfR (n = 74, P=0.0001) and neonatal birth weight (p < 0.0001) among siblings. High rates of preterm birth/LBW and low TBI stores at birth suggest the need for more data on determinants of Fe status and anemia in this group. Grant Funding Source : Supported by the Gerber Foundation