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CALERIE II: the effect of 25% calorie restriction over two years on cognitive function (629.7)
Author(s) -
Scott Tammy,
Das Sai,
Martin Corby,
Stewart Tiffany,
Williamson Donald,
Stein Rick,
Bhapkar Manjushri,
Pieper Carl,
Rochon James,
Roberts Susan
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.629.7
Subject(s) - cognition , medicine , randomized controlled trial , calorie , population , vigilance (psychology) , calorie restriction , working memory , gerontology , psychology , psychiatry , environmental health , neuroscience
Calorie restriction (CR) extends lifespan in a range of animal models and potentially decreases disease risk factors in humans. It is unclear, however, how CR impacts cognition; a negative outcome could decrease the feasibility and practicality of CR for health improvement. Previous studies in both animal models and humans have provided inconsistent findings reporting either positive, negative, or no effects. Our objective was to study the effect of CR on cognition during a 2‐year, multi‐center, randomized controlled trial. The analysis population was comprised of 218 healthy normal‐ and over‐weight adult volunteers who were enrolled into the CALERIE study, were randomized 2:1 into a 25% CR or an Ad Libitum control group, and began intervention. Cognition was measured through a computerized battery of tests (reaction time, attention/vigilance, verbal and visual memory, working memory, and executive function) at baseline, and 6‐, 12‐, and 24‐month follow‐up. Analysis was on an intention‐to‐treat basis, with models adjusted for study site, sex, baseline BMI stratum (18.5 ‐ 24.9 kg/m2 and 25 ‐ 28.9 kg/m2), baseline scores, age and education. Our results showed no consistent main effect of study intervention for any of the cognitive tests, nor a significant interaction between intervention and BMI stratum. Our null findings suggest that cognitive outcome is not a limitation for the use of CR for health improvement. Grant Funding Source : Supported by: USDA agreement No. 58‐1950‐0‐014 and NIA grant No. U01AG022132