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Chronic administration of Artemisia annua L. attenuates oxidative stress induced by D‐galactose in mice (629.10)
Author(s) -
Kim Mi Hye,
Seo Ji Yeon,
Han Mi Kyung,
Kang Hye Ryung,
Kim Seong Soon,
Kim Bo Ram,
Zakharova Alexandra,
Woo Ji Eun,
Kim JongSang
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.629.10
Subject(s) - oxidative stress , galactose , lipid peroxidation , antioxidant , artemisia annua , chemistry , artemisia , pharmacology , biochemistry , traditional medicine , medicine , immunology , artemisinin , plasmodium falciparum , malaria
Artemisia annua L. (AA) is well known to contain a significant level of artemisinin which is an anti‐malarial agent and was also reported to have antitumor activity at high concentration. Our previous study, the ethanolic extract of Artemisia annua . L had in vitro antioxidant effect and induced antioxidant enzyme NQO1 activity in murine hepatoma Hepa1c1c7 cell line. In this study, we investigated whether or not AA attenuates oxidative stress and DNA damage induced by D‐galactose in mouse model. Our results indicated that D‐galactose treatment (6 weeks) caused cognitive impairment in Morris water maze test and produced oxidative stress as is evidenced by the increase of lipid peroxidation and high level of 8‐OH dG in plasma. Furthermore, we found that D‐galactose treatment caused several histological change in some tissues. The treatment for 6 weeks with AA extract attenuated cognitive impairment, lipid peroxidation and DNA damage, and induced some antioxidant enzyme activities in mice injected i.p. with D‐galactose. In conclusion, AA extract suppressed memory impairment induced by D‐galactose in mice, maybe through suppression of ROS generation by D‐galactose. Grant Funding Source : Supported by NRF‐2010‐0027204 and 2011‐0009782 and IPET (High Value‐added Food TechnologyDevelopment Program, 2012, 112066‐3), S. Korea