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Serum folate and colorectal adenoma in Korean adults (628.18)
Author(s) -
Park Young Mee,
Cho Chang Ho,
Kim Sung Hi,
Lee Jung Eun
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.628.18
Subject(s) - colorectal adenoma , medicine , colonoscopy , adenoma , odds ratio , confounding , gastroenterology , colorectal cancer , confidence interval , logistic regression , cancer
We investigated the association between serum folate levels and colorectal adenoma in a case‐control study of Korean adults. Participants underwent colonoscopy, and provided blood specimens and information on their socio‐demographic status and other risk factors for colorectal adenoma in a university hospital. Serum folate levels were measured by using the electrochemiluminescence immunoassay (ECLIA). Colorectal adenoma cases were determined through colonoscopy and histologic examinations. We included 113 cases (58 men and 55 women) of colorectal adenoma and 255 controls (69 men and 186 women). We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) using a multivariate logistic regression model. After adjusting for potential confounding factors, we found no significant association between serum folate levels and colorectal adenoma; multivariate ORs (95% CIs) for the highest tertile compared to the lowest tertile were 0.86 (0.31 to 2.39) in men and 1.12 (0.51 to 2.46) in women. In summary, we did not observe that serum folate levels were associated with colorectal adenoma in Korean adults. Grant Funding Source : This study was supported by National Research Foundation of Korea (2011‐0011028)