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25(OH)D serum levels 蠅 50 ng/mL may provide additional reduction in breast cancer risk (628.12)
Author(s) -
McDonnell Sharon,
French Christine,
Gorham Edward,
Garland Cedric
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.628.12
Subject(s) - medicine , breast cancer , vitamin d and neurology , hazard ratio , body mass index , incidence (geometry) , cohort , cancer , proportional hazards model , gastroenterology , confidence interval , physics , optics
Higher serum 25‐hydroxyvitamin D [25(OH)D] concentrations are associated with a lower risk of breast cancer. Serum levels in the range of 40 to 60 ng/mL could prevent a substantial number of breast cancer cases. This study examined the relationship between serum 25(OH)D and the incidence of breast cancer among women aged 60 years and older. The study included the 771 participants of the GrassrootsHealth cohort who were followed prospectively for a median of 12 months. There were 5 self‐reported incident breast cancer cases within the study period. The median 25(OH)D concentration in this cohort was 50 ng/ml and the median age was 65 years. Four of the five cases had 25(OH)D values below the median for the group as a whole. Cox multivariate regression was used to assess the association between serum 25(OH)D concentration and incidence of breast cancer, adjusting for age. The hazard ratio of breast cancer in participants with a serum 25(OH)D concentration < 50 ng/mL was 5.1 (95% CI=0.56, 45.7) compared to 蠅 50 ng/mL. Body mass index (BMI) was also found to be associated with breast cancer risk. BMI is likely to be in the causal sequence because similar vitamin D intakes result in lower concentrations of serum 25(OH)D in individuals with high BMI compared to leaner individuals. A limitation of this study was that its median 12 month follow‐up limited the possibility of finding statistical significance. The trend in this study suggests that serum 25(OH)D concentrations from 50‐80 ng/mL may provide additional benefit in the prevention of breast cancer.