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Intrauterine growth influences growth and body composition of Peruvian children (620.3)
Author(s) -
Mispireta Monica,
Zavaleta Nelly,
Merialdi Mario,
DiPietro Janet,
Putnick Diane,
Bornstein Marc,
Caulfield Laura
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.620.3
Subject(s) - pregnancy , anthropometry , medicine , gestation , fetus , body mass index , obstetrics , waist , gestational age , endocrinology , biology , genetics
Our objective was to test whether intrauterine growth in the second half of pregnancy is associated with anthropometric and body composition measures in early childhood. We used data from a prenatal zinc supplementation trial in Peru (n=177) to estimate fetal growth using serial ultrasound measures of head circumference, abdominal circumference, femur diaphysis length, and estimated fetal weight (20‐38 wk gestation), and measures of growth and body composition (weight, height, body mass index (BMI), waist circumference, sum of skinfolds, and fat and muscle areas of extremities) evaluated at a follow‐up visit at 4.5 y. We constructed separate linear regression models for each fetal size measure in mid‐gestation (20‐24 wk), end of pregnancy (36‐38 wk), and the net difference between them and each measure of growth and body composition in childhood. In models adjusted for child and maternal factors, measures of fetal size at end of pregnancy and the difference in fetal size between mid‐gestation and end of pregnancy were positively associated with measures of growth, adiposity, and lean body mass at 4.5y. None of the fetal size measures in mid‐pregnancy were associated with child size or body composition. These results suggest that the fetal growth during the final few weeks of pregnancy influences size and body composition in early childhood. Grant Funding Source : Supported by Nestle Research Foundation; HD042675; NICHD; American Heart Association