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Energy balance induced by fluoxetine: possible involvement of body heat expenditure (575.1)
Author(s) -
Silva Aline Isabel,
Pedroza Anderson Apolonio,
Freitas Cristiane,
Braz Glauber Ruda,
Ferreira Diorginis,
Lagranha Claudia,
ManhaesdeCastro Raul
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.575.1
Subject(s) - endocrinology , medicine , superoxide dismutase , chemistry , malondialdehyde , catalase , reactive oxygen species , glutathione , antioxidant , dismutase , oxidative stress , biology , biochemistry , enzyme
Innumerous studies have shown that modulation of serotonin system can contributes to modulation of body weight. It is well known that the control of body weight is dependent of calories intake and energy expenditure and the major tissues related to energy expenditure are brown fat and skeletal muscle. During the metabolic process related to energy balance occurs formation of reactive oxygen species‐ROS. With these our aim was evaluate the effect fluoxetine‐FX on body weight, food intake, voluntary activity, body temperature, malondialdehyde production and superoxide dismutase‐SOD, catalase‐CAT and glutathione S‐transferase‐GST activity in brown adipocytes‐BA and extensor digitorum longus‐EDL. The treatment was conducted during the lactation time using 10mg/Kg‐B.W in male Wistar rats. We observe that FX treatment doesn’t induce alteration in food intake and voluntary activity, although induce decrease in body weight and lower heat loss after challenge with cold environment. Related to ROS, in EDL we observe increase in MDA production, decrease in GST activity and no differences in SOD and CAT; in BA we observe also an increase in MDA production and no difference in antioxidant enzymes. Our data suggest that modulation of serotonin levels by fluoxetine promotes decrease in body weight likely due to alteration in body heat expenditure and modulation of cellular ROS detoxification.