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Exercise training attenuates alterations in blood pressure and heart rate variability in old ovariectomized rats under fructose consumption (546.2)
Author(s) -
Machi Jacqueline,
Bernardes Nathalia,
Dias Danielle,
MoraesSilva Ivana,
Santos Fernando,
Wichi Rogerio,
De Angelis Katia,
Irigoyen Maria Claudia
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.546.2
Subject(s) - ovariectomized rat , endocrinology , medicine , fructose , heart rate , insulin resistance , blood pressure , treadmill , chemistry , adipose tissue , insulin , estrogen , biochemistry
The aim of the present study was to investigate the effects of exercise trainig (ET) in metabolic and cardiovascular parameters of old Wistar female under 24 months old. Female rats were ovariectomized and trained on a treadmill (1 h/day; 5 days/wk for 8 wk). The animal had free access to standard chow and fructose solution (100g/L) in drinking water and divided into 3 groups: ovariectomized (O, n= 8), ovariectomized fructose (OF, n= 8) and trained ovariectomized fructose (TOF, n= 8). Adipose tissue, insulin resistance, physical capacity, blood pressure and heart rate variability were evaluated at the end of the protocol. The metabolic results showed that ET decreased the adipose tissue in OFT (TOF: 5.28±0.6; O: 6.5±0.7 vs. OF: 10.07±0.6 g) and insulin resistance (TOF: 5.0±0.2 vs. OF: 3.2±0.6 mg/dl/min). The physical capacity was increased in (TOF: 1.8±0.1) compared with sedentary (O:1.1±0.05; OF: 1.1±0.05 Km/h). ET attenuated the increase in MBP (TOF: 107±1: O:119±2; OF:119±2 mmHg). The same behavior was observed in SBP (TOF: 129±1; O:142±2; OF:143±2 mmHg) and DBP (TOF: 89±1; O:100±2; OF:98±2; mmHg). TOF group showed increased pulse interval variance (133.3±36 ms2) when compared with O (88.3±22 ms2) and OF (114±22 ms2). The cardiac sympathetic modulation was decreased in TOF (1.95±0.4 ms2) when compared with OF (4.18±0.8ms2.) while cardiac vagal modulation was increased (TOF: 76±2.7 vs. OF: 69±3.6 n.u.). Consequently, sympatho‐vagal balance was decreased in OFT (0.33±0.04) vs. OF group (0.52±0.09). A similar behavior was observed for sympathetic modulation of blood pressure (TOF: 30±2.5 vs. O 37±3.4; OF: 40±4.1). In conclusion, exercise training effectively improves metabolic and cardiovascular parameters (blood pressure increase and heart rate variability) altered by excessive fructose consumption in aged rats submitted to ovarian hormone deprivation.