Premium
Kruppel‐like factor‐3: role in lipid secretion, transport and beta oxidation (537.3)
Author(s) -
Alnassar Nafla,
Parhar Ranjit,
AlMohanna Futwan,
Hashmi Sarwar
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.537.3
Subject(s) - insulin resistance , biology , lipid metabolism , metabolic syndrome , effector , adipose tissue , lipid oxidation , nutrient sensing , carbohydrate metabolism , metabolic pathway , microbiology and biotechnology , type 2 diabetes , obesity , diabetes mellitus , endocrinology , metabolism , signal transduction , biochemistry , antioxidant
Lipid metabolic disorder is a critical risk factor for metabolic syndrome,triggering diseases like obesity and diabetes.Obesity raises the risk for many chronic illnesses including diabetes,and heart disease.A unifying view is that insulin resistance,which arises from an excess of body fat,links T2D to obesity.Consistent with this view it has been observed that fat deposition in insulin effector cells decreases their sensitivity to insulin causing insulin resistance.While genetics and environmental components play a major role in the onset of disease caused by fat accumulation.There has been progress in our understanding of metabolic diseases given the complexity of vertebrate systems that employ many factors acting in overlapping and partially redundant pathways.Highly complicated metabolic networks and sensing mechanisms coordinate the flow of fats through synthesis,storage and breakdown pathways and therefore a composite view of nutrient uptake,transport,storage and utilization is required for its understanding.Mammalian Krüppel‐like factors KLFs play essential function in over all energy metabolisms.Many important factors controlling energy metabolism are conserved between mammals and C.elegans providing a new and powerful strategy to dissect the role of KLF in molecular pathways involved in fat metabolism.The worm intestine is our model system where genetics,molecular biology,and cell biology are used to identify and understand genes required in fat metabolism.Thus,we have found an important role of worm KLF in FA biosynthesis,mitochondrial proliferation,lipid secretion,and beta‐oxidation.We have began to understand the mechanism by which KLF controls these events in lipid metabolism.We have recently observed that worm KLF3 selectively acts on insulin components to regulate insulin pathway activity.There are many factors that control energy metabolism and defects in this control system are implicated in the pathogenesis of human obesity and diabetes.