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Characterizing anemia due to malnutrition in roux‐en‐y gastric bypass surgery patients (47.8)
Author(s) -
Wright Breanne,
GletsuMiller Nana
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.47.8
Subject(s) - anemia , medicine , hemoglobin , ferritin , soluble transferrin receptor , gastroenterology , vitamin b12 , iron deficiency , malnutrition , serum iron , surgery , iron status
Roux‐en‐y gastric bypass surgery (RYGB) is effective for weight loss, but is commonly associated with anemia. Anemia may be caused by decreased dietary intake and intestinal absorption of nutrients, and changes in systemic inflammation following surgery. Objectives were to investigate the nutritional causes of anemia within a RYGB cohort (anemia prevalence, 17%). Systemic concentrations of hemoglobin, ferritin, serum transferrin receptor (sTfR), total iron binding capacity (TIBC), copper (Cu), vitamins B1, B6 and B12, folate, zinc (Zn), and C‐reactive protein (CRP) were determined using reference methods. Iron deficiency equaled having 蠅 2 abnormalities in: ferritin, sTfR, sTfR:ferritin, or TIBC. Subjects (N=23) were female, age 51 ± 2 years, 6 ± 1 years post surgery, and 74% Caucasian. Anemia was most commonly associated with iron deficiency (34.8%), either in isolation (17.4%) or combined with other nutrient deficiencies (B6, B12 and/or Zn, 17.4%). 26.1% of anemia was explained by combinations of deficiencies in Zn, Cu, B12, B6, B1 or folate; none of these nutrients caused anemia in isolation. Inflammation accounted for 4.3% of anemia and 34.8% of anemia remained unexplained. This study supports iron deficiency as a leading cause of anemia in RYGB patients and highlights the role of several other nutrients, emphasizing the importance of comprehensive nutritional assessment following RYGB. Grant Funding Source : Supported by International Copper Association