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Vitamin B12 supplementation during pregnancy and postpartum increases maternal plasma anti‐influenza IgA and ameliorates infant’s plasma AGP response (392.8)
Author(s) -
Siddiqua Towfida,
Ahsan Khalid,
Ahmed Shaikh,
Allen Lindsay,
Raqib Rubhana
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.392.8
Subject(s) - medicine , pregnancy , vitamin b12 , postpartum period , lactation , immune system , placebo , breast milk , immunoglobulin a , immunology , endocrinology , immunoglobulin g , biology , biochemistry , genetics , alternative medicine , pathology
There is no information about effects of vitamin B12 supplementation during pregnancy and postpartum on immune function in mothers and their offspring. Women (n=66, 18‐35 y, Hb <115 g/L, 11‐14 wk pregnant) were randomized to receive 250 μg B12/d or a placebo through 4 mo postpartum. Both groups also received 400 μg folic acid + 60 mg Fe. Women were immunized with HINI vaccine at 26‐28 wk gestation. Vitamin B12, HINI‐specific IgG and IgA antibody responses in plasma, and IgA responses in colostrum/breast milk; acute phase response proteins, High sensitivity C‐reactive protein (HsCRP) and acid glycoprotein (AGP) were analyzed in plasma. At baseline, 26% of women were B12 deficient, and 39% had marginal status. Supplementation led to B12 adequate status in 94% mothers. In both groups combined, cord plasma H1N1 IgG was correlated with maternal (r=0.25, p=0.04) and infant (r=0.41, p=0.001) H1N1 IgG at 4 mo. Pre and post immunization H1N1‐specific maternal plasma IgG were similar in both groups. Supplementation significantly increased geometric mean titers of H1N1‐specific IgA in mothers at 4 mo postpartum compared to placebo group (p=0.03). Maternal supplementation reduced plasma AGP concentrations in infants at 4 mo compared to placebo group (0.75 vs. 0.62 g/L; p=0.05). Supplementation of 250 μg B12/d through pregnancy and lactation improved humoral immune function in response to antenatal influenza immunization, and reduced acute phase response. Grant Funding Source : Nestle Foundation