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The SORT1 risk allele is associated with exaggerated postprandial lipaemia in young adults (383.5)
Author(s) -
Connors Kimberly,
Gnatiuk Elizabeth,
Shearer Jane,
Hoffman Eric,
Barfield Whitney,
Hittel Dustin
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.383.5
Subject(s) - postprandial , medicine , very low density lipoprotein , endocrinology , lipoprotein , meal , cholesterol , genotype , allele , chemistry , diabetes mellitus , biochemistry , gene
Elevations in low‐density lipoproteins (LDL), very‐low density lipoproteins (VLDL) and triglycerides (TG) in the postprandial state have a strong genetic component and recognized atherogenic potential. We sought to determine if there is a difference in postprandial lipaemia following an oral fat tolerance test when stratified by genotype at the SORT1 1p13 locus, the strongest LDL‐cholesterol associated locus identified to date. Thirty, healthy young adults (age=23.57) received a high fat, mixed meal (91 g, 55% kcal from fat). Blood samples drawn at fasting, 2, 4, 8 and 24 hrs postprandial, underwent comprehensive lipoprotein analyses via nuclear magnetic resonance profiling. At fasting, VLDL particles differed based upon SORT1 genotype (TT: 48.81±5.07 nmol/L versus TC/CC: 30.05±2.99 nmol/L, p=0.004). Major, risk allele homozygotes (TT) had significantly elevated area‐under‐the‐curve and mean concentration for VLDL particles, TG and VLDL‐TG (p<0.05). These results indicate increased fasting and postprandial exposure to atherogenic particles in TT homozygotes. This highlights SORT1 as a valuable target for identifying individuals for early, personalized interventions to prevent atherosclerosis.