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Formula with docosahexaenoic acid, prebiotics, and beta‐glucan supports respiratory and skin health in children (382.6)
Author(s) -
Scalabrin Deolinda,
Ribeiro Tereza,
Peixoto de Matto Angela,
Zhuang Weihong,
Stolz Suzanne,
Pontes Mariana,
Almeida Indhira,
Godoy Carolina,
Gatto Sara,
Leal Vivian,
Cabral G,
Ribeiro Hugo
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.382.6
Subject(s) - medicine , docosahexaenoic acid , micronutrient , infant formula , incidence (geometry) , allergy , gastroenterology , food science , pediatrics , fatty acid , polyunsaturated fatty acid , immunology , chemistry , physics , organic chemistry , pathology , optics
Background: Consumption of nutrients such as docosahexaenoic acid (DHA), prebiotics, and beta‐glucan have been associated with a decrease in the occurrence of allergic manifestations (AM). Objective: To assess if consumption of a follow‐up formula with these and other essential nutrients would affect incidence of AM in children. Methods: In this double‐blind, randomized, controlled trial, healthy 1‐4 year old children from 2 daycare centers in Brazil were fed 3 servings/day of a cow’s milk‐based follow‐up formula with DHA, prebiotics polydextrose (PDX) and galactooligosaccharides (GOS), and beta‐glucan (FF; n=125), or an unfortified cow’s milk‐based beverage (C; n=131) for up to 28 weeks. Occurrence of AM was assessed by study pediatricians and analyzed by the Cochran‐Mantel‐Haenszel test and the counting process of Andersen‐Gill. Results: The FF group had fewer episodes of AM, which included allergic rhinitis, conjunctivitis, wheezing, allergic cough, eczema, and urticaria (Table) and a lower hazard ratio for having AM (HR, 0.64; 95% CI 0.47‐0.89; p=0.007). Conclusions: A cow’s milk‐based formula with added DHA, PDX, GOS, and beta‐glucan and fortified with micronutrients including zinc, vitamin A, and iron, when consumed 3 times per day for 28 weeks by 1‐4 year old children, was associated with fewer allergic manifestations in the skin and the respiratory tract.