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Interactions between circadian gene variants and fatty acid intake for metabolic syndrome risk: a meta‐analysis from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (373.2)
Author(s) -
Dashti Hassan,
Smith Caren,
Tanaka Toshiko,
Ordovás José
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.373.2
Subject(s) - circadian rhythm , metabolic syndrome , insulin resistance , biology , endocrinology , medicine , physiology , circadian clock , insulin , obesity
The circadian system is the body’s endogenous clock that governs a wide range of physiological systems and behaviors, and is regulated primarily by light and food intake. Variants in genes encoding components of the system result in circadian dysregulation, and have recently been linked to metabolic syndrome (MetS). In order to identify modifiable factors to attenuate the risk of MetS in individuals susceptible to circadian dysregulation, we investigated relationships between diet and these genetic risk factors in eight studies from the CHARGE consortium (up to 10,495 European descent individuals). In fixed‐effects meta‐analyses, we evaluated interactions between fatty acid (FA) intake and 5 variants on MetS. No interaction reached significance after multiple correction testing. However, the rs1387153 variant near MTNR1B, which encodes a circadian hormone receptor, interacted nominally (P = 0.01) with polyunsaturated FA intake on HOMA‐IR (homeostasis model assessment of insulin resistance). Additionally, we explored the role of sleep duration as a modulator of dietary intake. Consistent with previous studies, sleep duration was associated with total (P=0.03) and saturated (P=0.02) FA intake, only in women. The current findings inform understanding of complex relationships between circadian and metabolic physiology and may be of application for personalized recommendations to reduce MetS burden.