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Body composition changes with calorie restriction: results from the CALERIE trial (371.6)
Author(s) -
Das Sai Krupa,
Roberts Susan,
Ravussin Eric,
Racette Susan,
Kraus William,
Saltzman Edward,
Bhapkar Manjushri,
Rochon James,
Redman Leanne
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.371.6
Subject(s) - waist , calorie restriction , medicine , circumference , body weight , calorie , composition (language) , body mass index , zoology , dual energy , obesity , randomized controlled trial , body fat percentage , endocrinology , bone mineral , biology , linguistics , philosophy , geometry , mathematics , osteoporosis
Calorie Restriction (CR) is the only non‐pharmacological intervention that extends lifespan in animal models. However, it is unclear whether humans can implement CR without negative effects on body composition and, if so, whether it has effects consistent with attenuated metabolic aging. Our objective was to evaluate the effect of prolonged CR on body composition changes in CALERIE, a 24 month multi‐center randomized clinical trial. 218 non‐obese (body mass index: 22‐27 kg/m²) adults aged 21 to 51 years were enrolled and randomly assigned to 25% CR (CR group) or an ad libitum control (AL group) using a 2:1 allocation. Outcomes included body weight, waist circumference, and body fat mas (FM) and fat‐free mass (FFM) assessed using dual‐energy x‐ray absorptiometry. There were significant decreases in body weight (‐7.5±0.4 vs. 0.1±0.5 kg), FM (‐5.3±0.3 vs. 0.4±0.4 kg), waist circumference (‐6.1±0.4 vs. 0.9±0.5 cm) and FFM (‐2.2±0.2 vs. ‐0.2±0.2 kg) in the CR group compared to the AL group at 24 months (all p<0.001). However, at 24 months the percentage of weight change as FFM was not significantly different between the AL and CR groups (P=0.31). CR results in substantial changes in body composition but relative losses of FFM and FM appear to be comparable to those occurring with equivalent changes in body weight as observed in this study. Grant Funding Source : National Institute on Aging: U01AG022132