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Factors associated to leptin longitudinal trends throughout pregnancy differ according to pre‐gestational BMI (371.4)
Author(s) -
FrancoSena Ana,
Oliveira Livia,
Pinto Thatiana de,
Farias Dayana,
Vaz Juliana dos,
Kac Gilberto
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.371.4
Subject(s) - leptin , medicine , body mass index , endocrinology , pregnancy , anthropometry , gestational age , prospective cohort study , gestation , longitudinal study , obesity , biology , genetics , pathology
Objective: To assess if longitudinal trends of leptin in pregnancy are influenced by biochemical, anthropometric and lifestyle factors in women with normal weight (NW) or excessive weight (WE) pre‐gestational body mass index (BMI). Methods: Prospective cohort of 232 pregnant women followed at 8‐13th, 20‐26th and 30‐36th gestational weeks. The effect of anthropometric, biochemical, sociodemographic and life‐style variables on longitudinal behavior of plasmatic leptin concentrations, stratifying for NW (18.5‐24.9kg/m2) and EW (蠅25kg/m2) pre‐gestational BMI was assessed through longitudinal linear mixed‐effects models. Results: Leptin median values were 20.4, 32.1, and 31.6 ng/dL, respectively for the 1st, 2nd and 3rd trimester. The multiple regression model for women with NW revealed associations of body weight (β=0.705, SE=0.110), quantitative insulin sensitivity check index (QUICKI) (β=‐59.197, SE=30.361), serum HDL‐cholesterol (β=0.231, SE=0.072) and C‐reactive protein (β=‐0.140, SE=0.067) with plasmatic leptin levels. In women with EW, serum HDL‐cholesterol (β=0.441, SE=0.145), body weight (β=0.663, SE=0.116), triglycerides levels (β=‐0.061, SE=0.027) and carbohydrate intake (β=0.029, SE=0.015) were significantly associated to leptin. Conclusion: Maternal weight, lipid profile, CRP and carbohydrate intake were associated with leptin changes throughout pregnancy, but some of these factors differ according to pre‐gestational BMI. Grant Funding Source : Supported by FAPERJ and CNPq