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Nutritional factors are associated with glycemic control among youth with type 1 diabetes (370.6)
Author(s) -
MayerDavis Elizabeth,
Lamichhane Archana,
Crandell Jamie,
Jaacks Lindsay,
Lawrence Jean
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.370.6
Subject(s) - glycemic , medicine , type 1 diabetes , calorie , type 2 diabetes , insulin , confounding , diabetes mellitus , endocrinology
Among youth with type 1 diabetes (T1D), we have previously shown that higher baseline intakes of n‐3 fatty acids and leucine are associated with preserved insulin secretion after two years. We extended this work to report the longitudinal associations of these and other nutritional factors with glycemic control (based on hemoglobin A1c, HbA1c). We included 996 T1D youth who had baseline and follow‐up HbA1c measurements (mean ± SD age, 10.7 ± 3.9 yrs; T1D duration, 9.4 ± 6.1 mos). Nutritional factors assessed at baseline included: breastfeeding status and timing of complimentary foods introduction; food frequency questionnaire estimated intake of leucine, carbohydrate, protein, fat, and fiber; and plasma biomarkers for Vitamins D and E, and EPA and DHA (n‐3 fatty acids). We fit linear regression models adjusted for baseline HbA1c, socio‐demographic variables, diabetes‐related variables including insulin regimen and dose, time between baseline and follow‐up visits, and other potential confounders including total calories. Higher intake of EPA (β= ‐0.06, p=0.006), protein (β= ‐0.002, p=0.049) and fat (β= ‐0.003, p=0.002) were each significantly associated with better follow‐up HbA1c. Higher carbohydrate intake was associated with worse HbA1c (β= 0.001, p=0.0003). In addition to the overall role of major macronutrients, n‐3 fatty acid intake, specifically EPA, may beneficially affect glycemic control. Grant Funding Source : NIDDK, CDC