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Risk factors for moderate inflammation in Chinese adults with and without central obesity (370.1)
Author(s) -
Thompson Amanda,
Houck Kelly,
Adair Linda,
GordonLarsen Penny,
Popkin Barry
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.370.1
Subject(s) - waist , medicine , inflammation , odds ratio , obesity , c reactive protein , odds , logistic regression
The relationship between lifestyle factors and inflammation varies by weight status. Whether the risk factors associated with inflammation differ with central obesity is less well understood, particularly in populations exposed to both the higher pathogen burdens and obesogenic behaviors associated with moderate elevations in C‐reactive protein (CRP). We examined the distribution of moderate inflammation (CRP 3‐10mg/L) with and without high waist circumference (WC) in 1190 adults participating in the China Health Nutrition Survey and tested whether the risk factors for inflammation differed between those with and without high WC. Men were less likely to have elevated CRP with high WC than women (43.9% vs. 72.3%, p<0.001). In men, better household sanitation was associated with greater odds of elevated CRP with high WC (OR: 1.57, 95%CI: 1.21‐2.03). In women, post‐secondary education (OR: 0.27, 95%CI: 0.11‐0.62) and high fat‐ high energy diets (OR: 0.47, 95%CI: 0.25‐0.87) were associated with lower odds of elevated CRP with high WC. Similar results were seen in household‐level analyses controlling for spousal similarities in dietary and sanitation exposures. These results document different underlying risk factors for inflammation in Chinese men and women, suggesting that sex‐specific strategies may be needed to prevent and treat inflammation. Grant Funding Source : Supported by NIH NICHD (K01 HD071948‐01)