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Central adiposity influences the relationship between 25(OH)D and indices of plasma insulin (37.7)
Author(s) -
Wright Christian,
WeinheimerHaus Eileen,
Fleet James,
Peacock Munro,
Campbell Wayne
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.28.1_supplement.37.7
Subject(s) - medicine , endocrinology , vitamin d and neurology , overweight , body mass index , insulin , obesity , chemistry
Low serum 25‐hydroxyvitamin D3 (25(OH)D) is inversely associated and central adiposity is positively associated with plasma insulin (INS) concentrations. We assessed whether the relationship between 25(OH)D and INS is confounded by central adiposity. 336 overweight and obese adults (age: 48 ± 8 y, BMI: 30 ± 3 kg/m2) from West Lafayette, IN (40.4°N) were studied. Among all subjects, vitamin D status was as follows: 2% deficient (8‐10 ng/ml); 26% insufficient (10‐20 ng/ml); 53% adequate (20‐30 ng/ml); and 19% proposed optimal (>30 ng/ml). After controlling for age, race, and sex, 25(OH)D was inversely correlated with indices of INS (fasting INS, r= ‐0.12; oral glucose challenge INS area under the curve (AUC), r= ‐0.12; HOMA‐IR, r= ‐0.12; all p<0.05). Android fat mass index was also correlated with indices of INS (fasting INS, r= 0.32; INS AUC, r= 0.32; HOMA IR, r= 0.31; p<0.001) and 25(OH)D (r= ‐0.11, p<0.05). Similar correlations were observed for trunk fat mass and trunk body fat percent. These correlations (p<0.001) between central adiposity and INS persisted after controlling for 25(OH)D. However, after adjusting for individual markers of central adiposity, the significant correlations between 25(OH)D and indices of plasma INS did not persist. Our data do not support an independent effect of 25(OH)D on INS, but suggest that 25(OH)D is a marker for the relationship between central adiposity and insulin sensitivity. Grant Funding Source : U.S. Whey Protein Research Consortium; NIH T32AG025671 and UL1 TR6